Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats
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Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats.
Non-entrapped and liposome-entrapped Clostridium perfringens neuraminidase (0.5-0.6 unit) was injected into rats and its fate as well as its effect on plasma and erythrocyte N-acetylneuraminic acid was investigated. The following observations were made. (1) Although removal of both non-entrapped and liposome-entrapped neuraminidase from the circulation was completed within 5h after injection, t...
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Meth 'A' tumour-bearing Balb 'C' and 6C3HED tumour-bearing C3H mice were injected with liposomes (3min sonication) as in (a)-(c) and in (d) and (e) respectively. In (c), liposomes were given immediately after the injection of 'empty' liposomes. All animals were killed 24h after treatment, and "'In was measured in the liver, spleen and tumours (interscapular area). Injectedliposomes contained 0....
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Bmk, G.. Eckhardt, S. J., Hall, T. C. & Winkler, A. (1973) Drug Therapy of Cancer, pp. 64-67, World Health Organisation, Geneva Elmendorff. H. von (1965) Fette Seven Anstrichm. 67,557-562 Harrap, K. R. (1976) in Scientific Foundations of Oncology (Symington, T. & Carter, R. L., eds.), pp. 641-654, William Heinemann, London Hecker, E., Bresch, H. & von Szczepanski, C. (1964) Angew. Chem. Int. Ed...
متن کاملLymphatic absorption and tissue disposition of liposome-entrapped [14C]adriamycin following intraperitoneal administration to rats.
The lymphatic absorption and tissue distribution of free [14C]Adriamycin, "empty" [3H]liposomes, free [14C]Adriamycin plus empty [3H]liposomes, and [14C]Adriamycin entrapped into [3H]liposomes have been examined at intervals after i.p. injection into rats. Following treatment with empty [3H]liposomes, almost 30% of the liposomal lipid marker was recovered in 24-hr thoracic duct lymph, but when ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1974
ISSN: 0306-3283
DOI: 10.1042/bj1400323